Description

n-Succinimidyl 4-Methyl-3-Trimethylstannyl-Benzoate is a specialized organotin reagent designed for efficient bioconjugation and labeling applications. Its core value lies in its dual functionality, combining an amine-reactive N-hydroxysuccinimide (NHS) ester with a versatile trimethylstannyl group for subsequent cross-coupling reactions. This compound is essential for researchers and manufacturers in pharmaceutical development, radiopharmaceutical synthesis, and advanced materials science who require precise and stable methods for attaching molecules to proteins, peptides, or other biomolecules.

Application

• Radiopharmaceutical Precursor: Key intermediate in the synthesis of radioiodinated compounds for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging agents.
• Bioconjugation Linker: Facilitates the stable attachment of small molecules, dyes, or drugs to antibodies, proteins, and peptides via its NHS ester group, with the stannyl group enabling further functionalization.
• Stille Cross-Coupling Reactions: Serves as a crucial organotin reagent in palladium-catalyzed cross-coupling to form carbon-carbon bonds, useful in constructing complex organic molecules and polymers.
• Proteomics Research: Used in the development of chemical probes and activity-based protein profiling (ABPP) reagents to study enzyme function and protein interactions.
• Diagnostic Kit Development: Employed in the manufacturing of immunoassay components and in-vitro diagnostic (IVD) reagents that require specific labeling.
• Materials Science: Building block for creating functionalized surfaces, nanoparticles, and polymers with tailored biological activity or sensing capabilities.

Basic Information

Item	Detail
Product Name	n-Succinimidyl 4-Methyl-3-Trimethylstannyl-Benzoate
CAS No.	1260152-46-2
Molecular Formula	C16H21NO4Sn
Molecular Weight	410.04 g/mol
Synonyms	4-Methyl-3-(trimethylstannyl)benzoic acid N-succinimidyl ester; 3-Trimethylstannyl-4-methylbenzoic acid N-hydroxysuccinimide ester; NHS ester of 4-Methyl-3-trimethylstannylbenzoic acid; SNAC Reagent; Organotin NHS Ester; Stannylbenzoyl NHS ester; Tin-labeled NHS ester; (4-Methyl-3-(trimethylstannyl)benzoyloxy)succinimide
EINECS	Contact for details

Quality Control

Every batch of n-Succinimidyl 4-Methyl-3-Trimethylstannyl-Benzoate is manufactured and tested under strict quality management systems. We ensure high purity and lot-to-lot consistency through comprehensive analytical techniques including NMR, HPLC, and elemental analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at -20°C under an inert atmosphere (argon or nitrogen) to prevent oxidation and hydrolysis. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Tin Content	Theoretical ± 2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.