Description

Sodiumhydroxy((1R,4R)-4-(Methoxycarbonyl)Cyclohexyl)Methanesulfonate CAS NO 1259393-34-4 is a high-purity, stereochemically defined sulfonate salt used as a critical intermediate in advanced pharmaceutical synthesis. Its value lies in providing a chiral, functionalized cyclohexane scaffold essential for constructing complex active pharmaceutical ingredients (APIs) with high stereochemical fidelity. This compound is primarily needed by R&D laboratories and production facilities in the pharmaceutical and fine chemical industries focused on developing novel therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small-molecule drugs, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and anti-inflammatory applications.
• Chiral Synthesis: Utilized in asymmetric synthesis and medicinal chemistry programs to introduce the (1R,4R)-configured cyclohexyl moiety into target molecules, ensuring correct biological activity.
• Process Chemistry: Serves as a standardized starting material or advanced intermediate in scale-up and kilo-lab production for clinical trial material (CTM) and commercial API manufacturing.
• Protease Inhibitor Research: Potential intermediate in the development of protease inhibitors, leveraging the methanesulfonate and ester functional groups.
• Chemical Biology: Used in the design and synthesis of chemical probes and tool compounds for target validation and mechanistic studies in biological systems.
• Custom Synthesis: Foundation for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services for client-specific molecular entities.

Basic Information

Product Name	Sodiumhydroxy((1R,4R)-4-(Methoxycarbonyl)Cyclohexyl)Methanesulfonate
CAS No.	1259393-34-4
Molecular Formula	C10H17NaO7S
Molecular Weight	304.29 g/mol
Synonyms	Sodium ((1R,4R)-4-(methoxycarbonyl)cyclohexyl)(hydroxy)methanesulfonate; (1R,4R)-Methyl 4-((hydroxy(sodiosulfo)methyl)cyclohexane-1-carboxylate; Sodium (1R,4R)-4-(methoxycarbonyl)cyclohexyl(hydroxy)methanesulfonate; Sodium Hydroxy((1R,4R)-4-(Methoxycarbonyl)Cyclohexyl)Methanesulfonate; (1R,4R)-Cyclohexanecarboxylic acid, 4-((hydroxy(sodiosulfonyl)methyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Sodiumhydroxy((1R,4R)-4-(Methoxycarbonyl)Cyclohexyl)Methanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing comprehensive test results, including chiral purity and residual solvent analysis, are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.