Description

5-Bromo-2-(Difluoromethoxy)Aniline is a specialized aromatic amine derivative featuring bromine and difluoromethoxy substituents, making it a valuable fluorinated building block in advanced synthesis. This compound is critical for introducing specific structural motifs that can enhance the biological activity and metabolic stability of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve lipophilicity and systemic activity.
• Material Science: Acts as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Synthesis: Employed as a versatile building block for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl and heterocyclic structures.
• Dye and Pigment Industry: Functions as an intermediate for synthesizing novel fluorinated dyes and pigments with enhanced lightfastness and chemical resistance.

Basic Information

Product Name	5-Bromo-2-(Difluoromethoxy)Aniline
CAS No.	1258650-63-3
Molecular Formula	C7H6BrF2NO
Molecular Weight	238.03 g/mol
Synonyms	2-Amino-4-bromo-1-(difluoromethoxy)benzene; 4-Bromo-2-(difluoromethoxy)aniline; 5-Bromo-2-(difluoromethoxy)benzenamine; 1-Bromo-4-(difluoromethoxy)-2-aminobenzene; 2-(Difluoromethoxy)-5-bromoaniline; Benzenamine, 5-bromo-2-(difluoromethoxy)-; 1258650-63-3
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(Difluoromethoxy)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light). For long-term storage, consider under an inert atmosphere to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.