Description

1,4-Butanediol, 1,4-Bis(4-Nitrophenyl)-, 1,4-Dimethanesulfonate, (1R,4R)- is a high-purity, stereochemically defined synthetic intermediate of significant value in advanced pharmaceutical research and development. This compound matters for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals. Pharmaceutical companies, contract research organizations (CROs), and advanced material scientists need it for developing novel therapeutic agents, where precise stereochemistry and high purity are non-negotiable for efficacy and regulatory approval.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• API Development: Serves as a building block for constructing the core scaffold of complex small-molecule Active Pharmaceutical Ingredients (APIs) requiring specific (1R,4R) stereochemistry.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to introduce defined chiral centers into target molecules, crucial for producing enantiomerically pure compounds.
• Process Chemistry & Scale-Up: Used in research to develop and optimize scalable synthetic routes from laboratory to pilot plant and commercial production.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways and target validation.
• Advanced Material Research: Potential precursor for specialty polymers or liquid crystals where the nitro and sulfonate functional groups impart specific electronic or self-assembly properties.

Basic Information

Item	Detail
Product Name	1,4-Butanediol, 1,4-Bis(4-Nitrophenyl)-, 1,4-Dimethanesulfonate, (1R,4R)-
CAS No.	1258235-05-0
Molecular Formula	C20H24N2O10S2
Molecular Weight	516.54 g/mol
Synonyms	(1R,4R)-1,4-Bis(4-nitrophenyl)-1,4-butanediol dimethanesulfonate; (1R,4R)-1,4-Bis(p-nitrophenyl)butane-1,4-diyl dimethanesulfonate; (1R,4R)-Bis(4-nitrophenyl)butanediol dimesylate; (1R,4R)-BNBD Dimesylate; (R,R)-1,4-Bis(4-nitrophenyl)butane-1,4-diyl bis(methanesulfonate); (R,R)-BNBD Dimethyl Sulfonate; 1,4-Bis(4-nitrophenyl)-1,4-butanediol dimethanesulfonate (R,R)-isomer
EINECS	Contact for details

Quality Control

Our 1,4-Butanediol, 1,4-Bis(4-Nitrophenyl)-, 1,4-Dimethanesulfonate, (1R,4R)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral assay, NMR, and mass spectrometry for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.