Description

4-(3-Trifluoromethylphenoxy)Methyltetrahydro-2H-Pyran is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of a tetrahydropyran ring and a trifluoromethylphenoxy moiety, which imparts desirable physicochemical properties for creating novel molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, where the introduction of fluorine atoms is a key strategy to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for specialty monomers or additives aimed at developing polymers with enhanced chemical resistance, thermal stability, or specific surface properties.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands or organocatalysts for asymmetric synthesis applications.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination methodologies or studying the structure-activity relationships (SAR) of fluorinated compounds.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D programs.

Basic Information

Product Name	4-(3-Trifluoromethylphenoxy)Methyltetrahydro-2H-Pyran
CAS No.	1257664-95-1
Molecular Formula	C13H15F3O2
Molecular Weight	260.25 g/mol
Synonyms	4-[(3-Trifluoromethylphenoxy)methyl]tetrahydro-2H-pyran; Tetrahydro-2H-pyran-4-ylmethyl 3-(trifluoromethyl)phenyl ether; 3-(Trifluoromethyl)phenyl tetrahydro-2H-pyran-4-ylmethyl ether; 4-[(3-(Trifluoromethyl)phenoxy)methyl]tetrahydro-2H-pyran; THP-OTf derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4-(3-Trifluoromethylphenoxy)Methyltetrahydro-2H-Pyran is produced under a strict quality management system. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from techniques such as HPLC, GC, NMR, and mass spectrometry. Our commitment to supply chain integrity and traceability ensures you receive a reliable product for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.