Description

3-Cyclopropyl-1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazole is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures with precision. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group acts as a versatile handle for forming carbon-carbon bonds with aryl or vinyl halides, a cornerstone reaction in medicinal and process chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the pyrazole core's bioactivity.
• Ligand and Catalyst Development: The pyrazole-boronate structure can be utilized to create novel ligands for catalysis or functional materials.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a linker or functional component in the design of bifunctional molecules for targeted protein degradation.
• Material Science Research: Investigated as a monomer or precursor for constructing organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Cyclopropyl-1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazole
CAS No.	1257637-82-3
Molecular Formula	C13H21BN2O2
Molecular Weight	248.13 g/mol
Synonyms	3-Cyclopropyl-1-methyl-1H-pyrazole-4-boronic acid pinacol ester; 3-Cyclopropyl-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Methyl-3-cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 3-Cyclopropyl-1-methyl-4-boronic acid pinacol ester pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclopropyl-1-methyl-1H-pyrazole; 3-Cyclopropyl-1-methylpyrazole-4-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 3-Cyclopropyl-1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazole is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with exacting purity standards suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to maintain stability. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.