Description

Piperazin-1-Yl(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanone Hydrochloride is a high-value pharmaceutical intermediate and building block featuring a piperazine amide core and a pinacol boronate ester functional group. This compound matters as a critical synthon in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions for the construction of complex biaryl structures. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety serves as a versatile handle for palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new molecular entities.
• Agrochemical Synthesis: Intermediate in the development of new pesticides and herbicides requiring specific aryl-aryl linkages.
• Chemical Biology Probes: Useful for creating tagged molecules to study biological pathways and protein interactions.
• Advanced Materials Development: A precursor for organic electronic materials and liquid crystals where precise molecular architecture is crucial.

Basic Information

Product Name	Piperazin-1-Yl(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanone Hydrochloride
CAS No.	1256360-65-2
Molecular Formula	C17H26BClN2O3
Molecular Weight	352.66 g/mol
Synonyms	1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]piperazine hydrochloride; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid piperazin-1-yl amide hydrochloride; (4-(Piperazine-1-carbonyl)phenyl)boronic acid pinacol ester hydrochloride; 4-Piperazin-1-ylcarbonylphenylboronic acid pinacol ester hydrochloride; Piperazine-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone HCl
EINECS	Contact for details

Quality Control

Our production of Piperazin-1-Yl(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanone Hydrochloride adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity and NMR confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.