Description

n-[(8α,9S)-Cinchonan-9-Yl]-3,5-Bis(Trifluoromethyl)-Benzenesulfonamide is a high-value, organocatalytic intermediate derived from cinchona alkaloid chemistry. This compound is prized for its role as a highly effective chiral catalyst or ligand in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is essential for R&D and manufacturing chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Catalysis: As a chiral organocatalyst for enantioselective carbon-carbon and carbon-heteroatom bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Critical for the production of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Ligand in Metal Complexes: Used to create chiral metal complexes for transition metal-catalyzed asymmetric transformations.
• Agrochemical Research: Employed in the synthesis of chiral bioactive compounds for crop protection agents.
• Methodology Development: A key reagent in academic and industrial R&D for developing new synthetic methodologies.
• Fine Chemical Production: For the manufacture of specialty chemicals, flavors, and fragrances where optical purity is paramount.

Basic Information

Product Name	n-[(8α,9S)-Cinchonan-9-Yl]-3,5-Bis(Trifluoromethyl)-Benzenesulfonamide
CAS No.	1253690-78-6
Molecular Formula	C₂₈H₂₅F₆N₃O₂S
Molecular Weight	581.57 g/mol
Synonyms	(8α,9S)-N-[3,5-Bis(trifluoromethyl)phenyl]sulfonyl]cinchonan-9-amine; 3,5-Bis(trifluoromethyl)-N-[(8α,9S)-cinchonan-9-yl]benzenesulfonamide; Cinchona Alkaloid Sulfonamide Derivative; (DHQD)₂PYR Family Ligand Analog; Chiral Benzenesulfonamide Catalyst; Asymmetric Phase Transfer Catalyst Precursor
EINECS	Contact for details

Quality Control

Every batch of our n-[(8α,9S)-Cinchonan-9-Yl]-3,5-Bis(Trifluoromethyl)-Benzenesulfonamide is produced under strict quality management systems. We guarantee high chemical and chiral purity through comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) confirming identity, purity, and enantiomeric excess is provided with each shipment to ensure it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.