Description

4-Chloro-2-(Difluoromethoxy)Aniline is a specialized aromatic amine building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining halogen and difluoromethoxy substituents to impart specific electronic and steric properties to target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where it serves as a key intermediate.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated aniline core.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced organic materials with tailored properties.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for metal catalysts used in asymmetric synthesis and other complex organic transformations.
• Dye and Pigment Intermediate: Acts as a precursor in the synthesis of specialized dyes and pigments requiring halogen and fluorine-containing backbones for enhanced stability or color properties.

Basic Information

Product Name	4-Chloro-2-(Difluoromethoxy)Aniline
CAS No.	1250677-10-1
Molecular Formula	C7H6ClF2NO
Molecular Weight	193.58 g/mol
Synonyms	2-(Difluoromethoxy)-4-chloroaniline; 4-Chloro-2-(difluoromethoxy)benzenamine; 1-Amino-4-chloro-2-(difluoromethoxy)benzene; Benzenamine, 4-chloro-2-(difluoromethoxy)-; 4-Chloro-2-difluoromethoxyaniline; 4-Chloro-α,α-difluoro-o-anisidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Difluoromethoxy)Aniline is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is light-sensitive and easily oxidized; it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.