Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1S,2S)-2-(1-Pyrrolidinyl)Cyclohexyl]-Thiourea is a high-purity, chiral thiourea derivative designed for advanced chemical synthesis and research. This compound is valued for its role as a sophisticated organocatalyst and a key pharmaceutical intermediate in the development of novel therapeutics. It is essential for research institutions and pharmaceutical companies engaged in asymmetric synthesis, medicinal chemistry, and the development of enzyme inhibitors.

Application

• Asymmetric Organocatalysis: Serves as a highly effective hydrogen-bond donor catalyst for enantioselective organic transformations.
• Pharmaceutical Intermediate: A critical building block in the synthesis of complex, biologically active molecules, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and high-throughput screening for drug discovery programs.
• Chemical Biology Probe: Acts as a selective ligand or inhibitor for studying protein function and biological pathways.
• Chiral Auxiliary/Resolving Agent: Employed in the separation of enantiomers or the induction of chirality in synthetic sequences.
• Advanced Material Synthesis: A precursor for creating specialized ligands used in coordination chemistry and material science.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1S,2S)-2-(1-Pyrrolidinyl)Cyclohexyl]-Thiourea
CAS No.	1248348-67-5
Molecular Formula	C21H25F6N3S
Molecular Weight	465.50 g/mol
Synonyms	(1S,2S)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2-(pyrrolidin-1-yl)cyclohexyl]thiourea; (1S,2S)-N-(3,5-Bis(trifluoromethyl)phenyl)-N'-(2-(pyrrolidin-1-yl)cyclohexyl)thiourea; (1S,2S)-2-(1-Pyrrolidinyl)-N-[3,5-bis(trifluoromethyl)phenyl]-N'-cyclohexylthiourea; Chiral Thiourea Catalyst; BTPT; Organocatalyst 1248348-67-5; (S,S)-Thiourea Derivative
EINECS	Contact for details

Quality Control

Our n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1S,2S)-2-(1-Pyrrolidinyl)Cyclohexyl]-Thiourea is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral integrity. We adhere to cGMP guidelines where applicable, and our analytical methods (including HPLC, NMR, and chiral analysis) are validated to meet rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.