Description

4-Methanesulfonyl-Tetrahydro-Pyran-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a unique sulfonyl-substituted tetrahydropyran carboxylic acid structure. This compound is a critical building block in modern medicinal chemistry, valued for its ability to introduce specific steric and electronic properties into target molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of complex drug candidates, especially those requiring a sulfonyl-substituted heterocyclic moiety.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to modulate the physicochemical properties and biological activity of new chemical entities.
• Protease Inhibitor Development: The sulfonyl and carboxylic acid groups make it a potential precursor for designing inhibitors of various enzymes, including proteases and kinases.
• Chemical Biology Probes: Employed in the creation of tool compounds and molecular probes for investigating biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	4-Methanesulfonyl-Tetrahydro-Pyran-4-Carboxylic Acid
CAS No.	1247919-19-2
Molecular Formula	C8H14O5S
Molecular Weight	222.26 g/mol
Synonyms	4-(Methanesulfonyl)oxane-4-carboxylic acid; Tetrahydro-4-(methylsulfonyl)-2H-pyran-4-carboxylic Acid; 4-Methanesulfonyl-tetrahydropyran-4-carboxylic acid; 4-(Methylsulfonyl)tetrahydro-2H-pyran-4-carboxylic acid; 4-Carboxy-4-(methylsulfonyl)tetrahydropyran
EINECS	Contact for details

Quality Control

Our 4-Methanesulfonyl-Tetrahydro-Pyran-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with client specifications and relevant industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.