Description

2-Chloro-4-(Difluoromethoxy)Aniline (Wxfc0705) is a specialized aniline derivative featuring both chloro and difluoromethoxy substituents, making it a valuable fluorinated aromatic amine building block. This compound is essential for synthesizing advanced molecules where the introduction of fluorine atoms can dramatically alter physical, chemical, and biological properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors and other small-molecule therapeutics where fluorine substitution is critical for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance lipophilicity and target binding.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialized polymers, liquid crystals, or organic electronic materials that require fluorinated aromatic components.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments where halogen and fluorine groups influence color fastness and spectral properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) to construct more complex nitrogen-containing heterocycles and aromatic systems.

Basic Information

Product Name	2-Chloro-4-(Difluoromethoxy)Aniline (Wxfc0705)
CAS No.	1247745-21-6
Molecular Formula	C7H6ClF2NO
Molecular Weight	193.58 g/mol
Synonyms	2-Chloro-4-(difluoromethoxy)benzenamine; 4-Amino-3-chloro-1-(difluoromethoxy)benzene; 1-Chloro-2-amino-5-(difluoromethoxy)benzene; Benzenamine, 2-chloro-4-(difluoromethoxy)-; WXFC0705; 2-Chloro-4-difluoromethoxyaniline; 3-Chloro-4-(difluoromethoxy)aniline
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-(Difluoromethoxy)Aniline is manufactured and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure the material meets your precise research and development requirements. Our standard grade is suitable for industrial R&D, and we can discuss custom synthesis to meet specific purity benchmarks (e.g., >98% or >99% by HPLC) for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its amine functionality and light-sensitive nature, prolonged exposure to air and light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.