Description

1-Bromo-3-(Chloromethyl)-2-Methoxybenzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the presence of two distinct, reactive halogen sites—bromine and chloromethyl—which allow for sequential and selective functionalization. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, such as active pharmaceutical ingredients (APIs) and specialty chemical intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those requiring selective aromatic substitution patterns.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the methoxy and halogen groups impart specific biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine or nitrogen-based ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of functionalized monomers for specialty polymers, liquid crystals, or organic electronic materials.
• Cross-Coupling Reactions: The bromoaryl moiety is an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Substitution: The reactive chloromethyl group allows for further elaboration via substitution with various nucleophiles (e.g., amines, thiols).

Basic Information

Item	Detail
Product Name	1-Bromo-3-(Chloromethyl)-2-Methoxybenzene
CAS No.	1247514-62-0
Molecular Formula	C8H8BrClO
Molecular Weight	235.51 g/mol
Synonyms	2-Bromo-6-(chloromethyl)anisole; 3-Bromo-2-methoxybenzyl chloride; 1-Bromo-3-(chloromethyl)-2-methoxybenzene; (2-Bromo-6-methoxyphenyl)methyl chloride; 2-Methoxy-6-(chloromethyl)bromobenzene; 6-Bromo-2-(chloromethyl)anisole
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(Chloromethyl)-2-Methoxybenzene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.