Description

4-(Methylsulfonyl)-Tetrahydro-2H-Pyran-4-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonyl and nitrile functional groups on a tetrahydropyran scaffold. This compound is of significant value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific molecular motifs for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis due to its reactive nitrile and sulfonyl moieties.
• Agrochemical Synthesis: Employed in the development of new herbicides, fungicides, and insecticides where the tetrahydropyran structure confers specific biological activity.
• Fine Chemical Production: Acts as a building block for synthesizing specialty chemicals, dyes, and functional materials requiring specific heterocyclic architectures.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial-scale manufacturing of target molecules.

Basic Information

Product Name	4-(Methylsulfonyl)-Tetrahydro-2H-Pyran-4-Carbonitrile
CAS No.	1247418-40-1
Molecular Formula	C7H11NO3S
Molecular Weight	189.23 g/mol
Synonyms	4-(Methylsulfonyl)oxane-4-carbonitrile; Tetrahydro-2H-pyran-4-carbonitrile, 4-(methylsulfonyl)-; 4-(Methanesulfonyl)tetrahydro-2H-pyran-4-carbonitrile; 4-Methylsulfonyl-tetrahydropyran-4-carbonitrile; 4-Cyano-4-(methylsulfonyl)tetrahydropyran; 4-(Methylsulfonyl)tetrahydropyran-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-(Methylsulfonyl)-Tetrahydro-2H-Pyran-4-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliable consistency and traceability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.