Description

Methyl(S,Z)-2-((tert-Butoxycarbonyl)Amino)-3-(2-(4-((3,4-Dichlorobenzyl)Oxy)Phenyl)-2,3-Dihydrobenzo[B][1,4]Dioxin-6-Yl)Acrylate is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical synthesis and research. This compound is critical for medicinal chemists developing novel therapeutic agents, particularly in the areas of kinase inhibition and targeted drug discovery. Its complex structure, featuring a benzodioxin core and a protected amino acrylate moiety, makes it an essential building block for constructing potent and selective bioactive molecules. Global pharmaceutical R&D and fine chemical synthesis facilities rely on this high-quality intermediate to accelerate their discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Kinase Inhibitor Development: Used in the research and production of potential kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Serves as a critical scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex Active Pharmaceutical Ingredients (APIs).
• Biochemical Tool Compound: Utilized in academic and industrial research laboratories as a probe to study specific biological mechanisms and protein interactions.
• Pre-clinical Development: Integral to the synthesis of compounds for pharmacological profiling, toxicology studies, and formulation development.

Basic Information

Product Name	Methyl(S,Z)-2-((tert-Butoxycarbonyl)Amino)-3-(2-(4-((3,4-Dichlorobenzyl)Oxy)Phenyl)-2,3-Dihydrobenzo[B][1,4]Dioxin-6-Yl)Acrylate
CAS No.	1246828-98-7
Molecular Formula	C32H31Cl2NO7
Molecular Weight	612.50 g/mol
Synonyms	(S,Z)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(2-(4-((3,4-dichlorobenzyl)oxy)phenyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylate; Methyl (2S)-2-[[(2-methylpropan-2-yl)oxycarbonyl]amino]-3-[2-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2,3-dihydro-1,4-benzodioxin-6-yl]prop-2-enoate; (S,Z)-Boc-AA-Intermediate; 1246828-98-7; Methyl (S,Z)-Boc-amino-benzodioxinyl acrylate derivative; Dihydrobenzodioxin acrylate intermediate; BOC-Protected Amino Acrylate Benzodioxin Derivative
EINECS	Contact for details

Quality Control

Our Methyl(S,Z)-2-((tert-Butoxycarbonyl)Amino)-3-(2-(4-((3,4-Dichlorobenzyl)Oxy)Phenyl)-2,3-Dihydrobenzo[B][1,4]Dioxin-6-Yl)Acrylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry to ensure identity and quality specifications are met. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability and consistency for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.