Description

1-(tert-Butyldimethylsilyloxy)-1-(2’-Trimethylsilyl)Ethynyl-Cyclopropane-D4 is a high-purity, deuterated building block of significant value in advanced organic synthesis. Its core value proposition lies in its dual silyl-protected functional groups and strategic deuterium labeling, enabling precise molecular construction and isotopic tracing. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and conducting sophisticated mechanistic studies.

Application

• Pharmaceutical Intermediate: A key deuterated synthon for the synthesis of complex drug candidates, leveraging its cyclopropane and alkyne functionalities.
• Isotope Labeling Studies: Used in mass spectrometry and NMR-based research for metabolic pathway tracing, pharmacokinetics (PK/PD), and reaction mechanism elucidation.
• Agrochemical Research: Serves as a building block for developing novel, labeled pesticides and herbicides with enhanced environmental or biological tracking capabilities.
• Material Science Precursor: Employed in the synthesis of specialized polymers or advanced organic materials where the deuterated core imparts specific physical properties.
• Cross-Coupling Reactions: The protected ethynyl group acts as a versatile handle for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry, particularly in reactions involving strained ring systems and silyl chemistry.

Basic Information

Product Name	1-(tert-Butyldimethylsilyloxy)-1-(2’-Trimethylsilyl)Ethynyl-Cyclopropane-D4
CAS No.	1246820-34-7
Molecular Formula	C14H22D4OSi2
Molecular Weight	270.55 g/mol
Synonyms	1-[(tert-Butyldimethylsilyl)oxy]-1-[(trimethylsilyl)ethynyl]cyclopropane-d4; Cyclopropane-d4, 1-[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(trimethylsilyl)ethynyl]-; Deuterated TBDMS/TMS Protected Ethynylcyclopropanol; 1-(TBDMSO)-1-((TMS)ethynyl)cyclopropane-d4; 1-(tert-Butyldimethylsilyloxy)-1-(trimethylsilylethynyl)cyclopropane-d4; 1-(TMS-ethynyl)-1-(TBDMS-oxy)cyclopropane-d4; Deuterated Silyl Ether Alkyne Cyclopropane Derivative
EINECS	Contact for details

Quality Control

Our 1-(tert-Butyldimethylsilyloxy)-1-(2’-Trimethylsilyl)Ethynyl-Cyclopropane-D4 is manufactured under strict quality protocols to ensure batch-to-batch consistency and high isotopic purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (D-content), and identity confirmation via spectroscopic methods. We adhere to cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and documentation for regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and volatility. Due to its moisture-sensitive and highly volatile nature, allow the container to reach room temperature before opening to prevent condensation and loss of product.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.