Description

6-Amino-2-Thiouracil-13C is a stable isotope-labeled derivative of 6-amino-2-thiouracil, where the carbon-13 (13C) isotope is incorporated at a specific position. This compound is essential for advanced analytical research, providing an internal standard for precise quantification and metabolic pathway tracing using techniques like mass spectrometry and nuclear magnetic resonance (NMR). It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors for drug metabolism and pharmacokinetics (DMPK) studies, biomarker discovery, and the development of sensitive analytical methods.

Application

• As an internal standard for the accurate quantification of 6-amino-2-thiouracil and related metabolites in biological matrices via LC-MS/MS.
• In drug metabolism and pharmacokinetics (DMPK) studies to elucidate the metabolic fate of pharmaceutical compounds.
• For biomarker research and development of diagnostic assays in clinical and preclinical settings.
• As a tracer compound in mechanistic studies of biochemical pathways involving pyrimidine analogs.
• In the synthesis of isotope-labeled complex molecules for use as reference materials in regulatory submissions.
• For NMR spectroscopy applications, where the 13C label aids in structural elucidation and dynamic studies.

Basic Information

Item	Detail
Product Name	6-Amino-2-Thiouracil-13C
CAS No.	1246816-15-8
Molecular Formula	C413CH5N3OS
Molecular Weight	~146.15 g/mol
Synonyms	6-Amino-2-mercapto-4-pyrimidinol-13C; 2-Thio-6-aminouracil-13C; 6-Amino-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one-13C; 6-Amino-2-thio-4-hydroxypyrimidine-13C; 2-Thio-6-aminobarbituric acid-13C; 13C-Labeled 6-Amino-2-thiouracil; Isotopically labeled 6-amino-2-thiouracil
EINECS	Contact for details

Quality Control

Our 6-Amino-2-Thiouracil-13C is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and structural identity. Certificates of Analysis (COA) are provided, detailing results for assay, isotopic purity (typically >99 atom % 13C), and key impurities. We support research requiring compliance with various pharmacopeial standards, and specifications can be tailored to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % 13C
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.