Description

(R)-Methyl 4-Aminochroman-6-Carboxylate Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. This compound is valued for its defined stereochemistry and functional groups, which are critical for synthesizing active pharmaceutical ingredients (APIs) with specific biological activity. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in the development of novel therapeutic agents.

Application

• Key Chiral Intermediate in the synthesis of novel pharmaceutical compounds, particularly for central nervous system (CNS) and cardiovascular targets.
• Building Block for medicinal chemistry research and structure-activity relationship (SAR) studies.
• Precursor in the development of chroman and tetrahydroquinoline-based drug candidates.
• Starting Material for the preparation of more complex, optically active molecules via further chemical modification.
• Reference Standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	(R)-Methyl 4-Aminochroman-6-Carboxylate Hydrochloride
CAS No.	1246509-59-0
Molecular Formula	C12H16ClNO3
Molecular Weight	257.71 g/mol
Synonyms	(R)-Methyl 4-amino-3,4-dihydro-2H-1-benzopyran-6-carboxylate hydrochloride; (R)-Methyl 4-aminochroman-6-carboxylate HCl; (R)-4-Aminochroman-6-carboxylic acid methyl ester hydrochloride; (R)-Methyl 4-amino-3,4-dihydro-2H-chromene-6-carboxylate hydrochloride; (R)-6-(Methoxycarbonyl)-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; CAS 1246509-59-0; (R)-4-Amino-6-(methoxycarbonyl)chroman hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Methyl 4-Aminochroman-6-Carboxylate Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.