Description

Potassium Trifluoro(2-(Methylthio)Pyrimidin-5-Yl)Borate is a specialized organoboron reagent, specifically a potassium trifluoroborate salt, designed for advanced synthetic applications. This compound matters as a stable, air- and moisture-tolerant alternative to boronic acids, enabling critical cross-coupling reactions with high efficiency and functional group tolerance. It is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require reliable building blocks for constructing complex heterocyclic scaffolds, such as pyrimidine derivatives, in drug discovery and development programs.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between the pyrimidine ring and various aryl or vinyl halides, crucial for synthesizing active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Serves as a vital building block in the multi-step synthesis of drug candidates, particularly those containing functionalized pyrimidine cores.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the 2-(methylthio)pyrimidine moiety imparts specific biological activity.
• Material Science Precursor: Potential use in creating organic electronic materials or metal-organic frameworks (MOFs) with tailored properties.
• Chemical Biology & Probe Development: Enables the labeling or modification of biomolecules for diagnostic and research tools.
• Process Chemistry & Scale-up: Its stability makes it suitable for optimizing and scaling up coupling reactions from laboratory to pilot plant scale.

Basic Information

Item	Detail
Product Name	Potassium Trifluoro(2-(Methylthio)Pyrimidin-5-Yl)Borate
CAS No.	1245906-73-3
Molecular Formula	C5H5BF3KN2S
Molecular Weight	232.07 g/mol
Synonyms	Potassium (2-(Methylthio)pyrimidin-5-yl)trifluoroborate; 2-(Methylthio)pyrimidin-5-yltrifluoroborate Potassium Salt; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(methylthio)pyrimidine (Protected precursor); 2-Methylsulfanylpyrimidine-5-trifluoroboronic acid potassium salt; (2-(Methylthio)pyrimidin-5-yl)trifluoroboranuide Potassium; Potassium Trifluoro((2-(methylthio)pyrimidin-5-yl))borate(1-); 5-Pyrimidinylboronic acid, 2-(methylthio)-, potassium trifluoroborate salt
EINECS	Contact for details

Quality Control

Our Potassium Trifluoro(2-(Methylthio)Pyrimidin-5-Yl)Borate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 19F, 11B), HPLC for purity, and KF titration for moisture content, to ensure compliance with exacting standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term stability. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
1H NMR Purity	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.