Description

Potassium Trifluoro(2-Fluoropyrimidin-5-Yl)Borate is a high-purity organoboron reagent, specifically a potassium trifluoroborate salt. This compound is a valuable synthetic building block, prized for its enhanced stability and handling properties compared to traditional boronic acids. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients through cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heteroaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate fluorinated pyrimidine motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Probe Development: Enables the synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Process Chemistry & Scale-up: Its stability makes it suitable for optimizing and scaling up coupling reactions in pilot plant and manufacturing settings.
• Academic & Contract Research: A critical tool in academic laboratories and CROs (Contract Research Organizations) for medicinal chemistry and methodology development.

Basic Information

Product Name	Potassium Trifluoro(2-Fluoropyrimidin-5-Yl)Borate
CAS No.	1245906-69-7
Molecular Formula	C4H2BF4KN2
Molecular Weight	203.98 g/mol
Synonyms	Potassium (2-Fluoropyrimidin-5-yl)trifluoroborate; 2-Fluoropyrimidin-5-yltrifluoroborate Potassium Salt; 5-(Trifluoroborato)-2-fluoropyrimidine Potassium Salt; Potassium 2-Fluoropyrimidine-5-trifluoroborate; 2-Fluoro-5-pyrimidyltrifluoroborate Potassium; (2-Fluoropyrimidin-5-yl)Potassium Trifluoroborate; Potassium Trifluoro(2-fluoropyrimidin-5-yl)borate(1-)
EINECS	Contact for details

Quality Control

Our Potassium Trifluoro(2-Fluoropyrimidin-5-Yl)Borate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as assay (by 19F/11B NMR or HPLC), identity confirmation, and moisture content. We support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) in a glovebox or using appropriate Schlenk techniques to prevent decomposition. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure (1H, 19F, 11B NMR)
Purity (NMR/HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.