Description

2-Chloro-4-(Tributylstannyl)Thiazole is a specialized organotin reagent featuring a functionalized thiazole heterocycle. This compound matters as a versatile building block in modern synthetic chemistry, enabling precise carbon-carbon bond formation via Stille cross-coupling reactions. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex thiazole-based heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific thiazole motifs.
• Material Science Research: Employed in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Stille Cross-Coupling Reactions: Serves as a pivotal organotin donor reagent for palladium-catalyzed coupling with aryl or vinyl halides.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel ligands and organometallic catalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems.

Basic Information

Product Name	2-Chloro-4-(Tributylstannyl)Thiazole
CAS No.	1245816-11-8
Molecular Formula	C15H28ClNSSn
Molecular Weight	424.66 g/mol
Synonyms	4-(Tributylstannyl)-2-chlorothiazole; 2-Chloro-4-tributylstannylthiazole; Thiazole, 2-chloro-4-(tributylstannyl)-; Tributyl(2-chloro-4-thiazolyl)stannane; 2-Chloro-4-(tributylstannyl)-1,3-thiazole; Stannane, tributyl(2-chloro-4-thiazolyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-(Tributylstannyl)Thiazole is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical synthetic applications. We employ advanced analytical techniques, including NMR, HPLC, and GC-MS, to verify identity, purity, and absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. Due to its moisture-sensitive and easily oxidized nature, the container should be allowed to reach ambient temperature before opening to minimize condensation and exposure to air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Tin (Sn) Content	27.0 - 28.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.