Description

Potassium Pyrimidine-5-Trifluoroborate is a high-value organotrifluoroborate salt, a crucial building block in modern synthetic chemistry. Its primary value lies in its exceptional stability and reactivity, making it a superior reagent for Suzuki-Miyaura cross-coupling reactions compared to traditional boronic acids. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require efficient, reliable methods for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing pyrimidine-containing active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that incorporate the pyrimidine moiety for enhanced biological activity.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Medicinal Chemistry & Drug Discovery: Enables rapid parallel synthesis and library generation for high-throughput screening of bioactive compounds.
• Chemical Biology Probes: Facilitates the labeling and modification of biomolecules for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses specializing in complex, multi-step organic synthesis for clients.

Basic Information

Product Name	Potassium Pyrimidine-5-Trifluoroborate
CAS No.	1242733-91-0
Molecular Formula	C4H3BF3KN2
Molecular Weight	177.99 g/mol
Synonyms	Potassium (Pyrimidin-5-yl)trifluoroborate; 5-Pyrimidyltrifluoroborate Potassium Salt; Pyrimidin-5-yltrifluoroboronic Acid Potassium Salt; Potassium Pyrimidin-5-yl-Trifluoroboronate; 5-Trifluoroboratopyrimidine Potassium Salt; Potassium 5-(Trifluoroboranyl)pyrimidine; 5-Pyrimidineboronic Acid, Trifluoro-, Potassium Salt
EINECS	Contact for details

Quality Control

Our Potassium Pyrimidine-5-Trifluoroborate is manufactured under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including NMR (1H, 13C, 11B, 19F), HPLC purity analysis, and KF titration for moisture content, to ensure it meets the high standards required for sensitive cross-coupling reactions. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) in a moisture-free environment to prevent decomposition. For long-term storage, consider storing under an inert gas blanket in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
11B NMR Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.