Description

(R)-6,8-Dichloro-Chroman-4-Ylamine is a chiral, halogenated chroman derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel pharmaceutical agents and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process R&D, and the synthesis of complex, optically active compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its chroman scaffold and halogen substituents.
• Asymmetric Synthesis: Employed as a chiral amine component in the synthesis of complex, enantiomerically pure molecules.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and route development for active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Can be utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(R)-6,8-Dichloro-Chroman-4-Ylamine
CAS No.	1241681-63-9
Molecular Formula	C9H9Cl2NO
Molecular Weight	218.08 g/mol
Synonyms	(R)-6,8-Dichloro-4-chromanamine; (4R)-6,8-Dichloro-3,4-dihydro-2H-1-benzopyran-4-amine; (R)-6,8-Dichloro-3,4-dihydro-2H-chromen-4-amine; (R)-6,8-Dichloro-4-aminochroman; (R)-6,8-Dichloro-2,3-dihydro-4H-1-benzopyran-4-amine; 1241681-63-9; (R)-enantiomer of 6,8-Dichloro-Chroman-4-Ylamine
EINECS	Contact for details

Quality Control

Our (R)-6,8-Dichloro-Chroman-4-Ylamine is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive pharmaceutical research. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles for the production of advanced intermediates, ensuring reliable batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Enantiomeric Purity (Chiral HPLC)	≥98.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.