Description

n-[(1R,2R)-2-[Bis(Phenylmethyl)Amino]Cyclohexyl]-N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea is a sophisticated chiral thiourea derivative, a class of compounds renowned for their utility as organocatalysts and ligands in asymmetric synthesis. This compound matters for its potential to impart high enantioselectivity in critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the production of optically pure intermediates. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals where stereochemical control is paramount.

Application

• Asymmetric Organocatalysis: Serving as a hydrogen-bond donor catalyst for enantioselective Michael additions, Mannich reactions, and aldol condensations.
• Pharmaceutical Intermediate Synthesis: Facilitating the stereocontrolled construction of complex molecular architectures in drug discovery and development pipelines.
• Chiral Ligand in Metal Complexes: Potentially acting as a bidentate ligand for transition metals to create catalysts for asymmetric hydrogenation or cross-coupling reactions.
• Academic & Industrial Research: A valuable tool compound for methodological development in synthetic organic chemistry laboratories.
• Fine Chemical Production: Enabling the scalable synthesis of enantiomerically enriched flavors, fragrances, and agrochemical intermediates.

Basic Information

Product Name	n-[(1R,2R)-2-[Bis(Phenylmethyl)Amino]Cyclohexyl]-N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea
CAS No.	1240466-16-3
Molecular Formula	C29H29F6N3S
Molecular Weight	565.62 g/mol
Synonyms	(1R,2R)-N,N-Dibenzyl-2-{[3,5-bis(trifluoromethyl)phenyl]carbamothioylamino}cyclohexanamine; N-[(1R,2R)-2-(Dibenzylamino)cyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]thiourea; Chiral Thiourea Organocatalyst; (R,R)-DACH-Thiourea Derivative; (1R,2R)-2-(Dibenzylamino)cyclohexyl-3,5-bis(trifluoromethyl)phenylthiourea; Bifunctional Thiourea Catalyst; Asymmetric Synthesis Catalyst 1240466-16-3
EINECS	Contact for details

Quality Control

Our production of this advanced chiral building block adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Every lot is characterized using advanced analytical techniques including HPLC, chiral HPLC, 1H/19F/13C NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97%), enantiomeric excess (ee), and impurity profile is provided with each shipment to support your critical R&D and cGMP-compliant workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.