Description

tert-Butyl ((3S,4S)-4-Hydroxytetrahydro-2H-Pyran-3-Yl)Carbamate is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for advanced synthesis projects.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for complex molecules requiring specific stereochemistry.
• Protease Inhibitor Research: Used in the development and production of protease inhibitors, a critical class of therapeutics.
• Peptidomimetic Chemistry: Serves as a protected amino acid derivative for constructing peptide-like structures with enhanced metabolic stability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce chiral centers.
• Agrochemical Development: Utilized in the research and production of advanced, enantiomerically pure agrochemicals.
• Custom Synthesis & Contract Manufacturing: A critical component for CDMOs (Contract Development and Manufacturing Organizations) serving the pharmaceutical and biotech sectors.

Basic Information

Product Name	tert-Butyl ((3S,4S)-4-Hydroxytetrahydro-2H-Pyran-3-Yl)Carbamate
CAS No.	1240390-33-3
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	(3S,4S)-3-[(tert-Butoxycarbonyl)amino]tetrahydro-2H-pyran-4-ol; Boc-(3S,4S)-4-Hydroxypiperidin-3-yl-carbamate (common mis-assignment based on ring size); tert-Butyl N-[(3S,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]carbamate; (3S,4S)-4-Hydroxy-N-Boc-3-aminotetrahydropyran; Boc-4-Hydroxy-3-aminotetrahydropyran ((3S,4S)- isomer); Carbamic acid, N-[(3S,4S)-4-hydroxy-3-tetrahydro-2H-pyranyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl ((3S,4S)-4-Hydroxytetrahydro-2H-Pyran-3-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.