Description

Potassium 6-Chloropyridine-3-Trifluoroborate is a versatile and valuable organoboron reagent, specifically a potassium trifluoroborate salt, widely used in modern synthetic chemistry. Its primary value lies in its enhanced stability and handling properties compared to boronic acids, making it a crucial building block for Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require the reliable introduction of the 6-chloropyridin-3-yl moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that incorporate chloropyridine structures.
• Material Science Research: Serves as a precursor for creating functionalized organic materials, such as ligands for catalysts or components for organic electronics.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and heterobiaryl bonds under mild conditions.
• Chemical Library Development: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in drug discovery.
• Ligand and Catalyst Design: Useful for synthesizing novel pyridine-based ligands used in homogeneous catalysis.

Basic Information

Product Name	Potassium 6-Chloropyridine-3-Trifluoroborate
CAS No.	1235099-38-3
Molecular Formula	C5H3BClF3KN
Molecular Weight	231.44 g/mol
Synonyms	Potassium (6-Chloropyridin-3-yl)trifluoroborate; 6-Chloro-3-pyridyltrifluoroboronic Acid Potassium Salt; (6-Chloropyridin-3-yl)trifluoroborate Potassium Salt; Potassium 6-Chloro-3-pyridyltrifluoroborate; 6-Chloropyridine-3-trifluoroboronate Potassium; 3-Trifluoroborato-6-chloropyridine Potassium Salt; 6-Chloro-3-pyridyl-BF3K; Potassium 6-Chloro-3-pyridyl-BF3
EINECS	Contact for details

Quality Control

Our Potassium 6-Chloropyridine-3-Trifluoroborate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 19F, 11B) and HPLC for identity and purity verification, to ensure it meets the high standards required for sensitive cross-coupling applications. Certificates of Analysis (COA) with full analytical data are provided for every shipment, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) and desiccated to prevent moisture absorption and decomposition. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
NMR Purity (19F)	≥ 95.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.