Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1S,2S)-2-(Dimethylamino)-1,2-Diphenylethyl]-Thiourea is a sophisticated chiral thiourea derivative, a class of compounds renowned for their utility as highly effective organocatalysts and asymmetric synthesis ligands. Its value lies in its ability to facilitate enantioselective transformations, which are critical for producing single-enantiomer active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst for enantioselective reactions such as Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: A key building block or chiral auxiliary in the synthesis of complex, single-enantiomer drug candidates and APIs.
• Ligand for Metal Complexes: Used to create chiral metal-ligand complexes for asymmetric catalysis, including hydrogenation and C-C bond formation.
• Agrochemical Research: Applied in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool compound for methodological development in organic synthesis and catalysis research.
• Material Science: Potential use in the synthesis of chiral polymers or as a component in sensor technology for chiral recognition.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1S,2S)-2-(Dimethylamino)-1,2-Diphenylethyl]-Thiourea
CAS No.	1233369-41-9
Molecular Formula	C25H21F6N3S
Molecular Weight	501.51 g/mol
Synonyms	(1S,2S)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2-(dimethylamino)-1,2-diphenylethyl]thiourea; (S,S)-Jacobsen Thiourea Catalyst Analogue; (1S,2S)-1,2-Diphenyl-N'-(3,5-bis(trifluoromethyl)phenyl)-N-(2-(dimethylamino)ethyl)ethane-1,2-diamine-1-carbothioamide; Chiral Bis(trifluoromethyl)phenyl Thiourea Derivative; Asymmetric Thiourea Organocatalyst; N-(3,5-Bis(trifluoromethyl)phenyl)-N'-((1S,2S)-2-(dimethylamino)-1,2-diphenylethyl)thiourea
EINECS	Contact for details

Quality Control

Our production of this advanced chiral compound adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, 1H/19F NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC assay), enantiomeric excess (ee), and impurity profile is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.