Description

3-(Aminomethyl)-5-(Trifluoromethyl)Aniline is a high-value, multi-functional aromatic amine building block featuring both an aminomethyl and a trifluoromethyl group on the benzene ring. This unique bifunctional structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and specialty agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate this potent pharmacophore into novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs, kinase inhibitors, and anti-inflammatory agents.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a building block for creating complex ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer & Material Science: Incorporated into specialty polymers, dyes, and pigments to impart unique chemical and thermal properties.
• Fluorinated Compound Research: A valuable reagent in academic and industrial R&D for exploring the effects of fluorine substitution in organic molecules.
• Cross-coupling Reactions: The aniline and benzylamine functionalities make it a versatile substrate for palladium-catalyzed coupling reactions like Buchwald-Hartwig amination.

Basic Information

Product Name	3-(Aminomethyl)-5-(Trifluoromethyl)Aniline
CAS No.	1233324-80-5
Molecular Formula	C8H9F3N2
Molecular Weight	190.17 g/mol
Synonyms	5-(Trifluoromethyl)-1,3-benzenedimethanamine; 3-(Aminomethyl)-5-(trifluoromethyl)benzenamine; 3-(Aminomethyl)-α,α,α-trifluoro-m-toluidine; 3-Aminomethyl-5-trifluoromethylaniline; m-(Aminomethyl)-α,α,α-trifluoroaniline; 3-(Trifluoromethyl)-5-(aminomethyl)aniline; 1-Amino-3-(aminomethyl)-5-(trifluoromethyl)benzene; Benzenemethanamine, 3-amino-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-(Aminomethyl)-5-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.