Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1S)-2'-(Dimethylamino)[1,1'-Binaphthalen]-2-Yl]- Thiourea is a sophisticated chiral thiourea derivative, recognized as a highly effective organocatalyst. This compound matters for its ability to facilitate asymmetric synthesis with excellent enantioselectivity, a critical requirement in modern pharmaceutical and fine chemical manufacturing. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex chiral molecules.

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst for a variety of enantioselective transformations, including Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Agrochemical Research: Applied in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Methodology Development: Serves as a benchmark catalyst in academic and industrial laboratories for developing new catalytic asymmetric protocols.
• Fine Chemical Production: Facilitates the production of specialty chemicals, flavors, and fragrances where stereochemical control is paramount.
• Material Science: Investigated for the synthesis of chiral polymers and functional materials with specific optical properties.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1S)-2'-(Dimethylamino)[1,1'-Binaphthalen]-2-Yl]- Thiourea
CAS No.	1229598-20-2
Molecular Formula	C₃₁H₂₂F₆N₄S
Molecular Weight	596.59 g/mol
Synonyms	(S)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2-(dimethylamino)-[1,1'-binaphthalen]-2-yl]thiourea; (S)-DTB; (S)-3,5-Bis(trifluoromethyl)phenyl(2'-dimethylaminobinaphth-2-yl)thiourea; Chiral Thiourea Catalyst; BINAP-Thiourea Derivative; Takemoto Catalyst Analog; Organocatalyst 1229598-20-2; Asymmetric Thiourea Catalyst
EINECS	Contact for details

Quality Control

Every batch of our n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1S)-2'-(Dimethylamino)[1,1'-Binaphthalen]-2-Yl]- Thiourea is synthesized and purified under controlled conditions to ensure high chiral purity and catalytic performance. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) providing detailed specifications for identity, purity (HPLC), enantiomeric excess (Chiral HPLC), and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.