Description

(4-Fluorotetrahydro-2H-Pyran-4-Yl)Methanamine is a high-value fluorinated heterocyclic amine building block, essential for introducing both fluorine and a basic amine moiety into complex molecular architectures. This compound matters for its role in medicinal chemistry and agrochemical research, where its unique scaffold is leveraged to modulate the physicochemical properties, metabolic stability, and binding affinity of target molecules. Pharmaceutical and agrochemical R&D teams need this specialized intermediate for the synthesis of novel active ingredients, particularly in the development of CNS-targeting drugs and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Fluorine Chemistry Research: A valuable substrate for exploring new fluorination reactions and the synthesis of complex fluorinated molecules.

Basic Information

Product Name	(4-Fluorotetrahydro-2H-Pyran-4-Yl)Methanamine
CAS No.	1228875-13-5
Molecular Formula	C6H12FNO
Molecular Weight	133.16 g/mol
Synonyms	4-(Aminomethyl)-4-fluorotetrahydro-2H-pyran; 4-Fluoro-4-(aminomethyl)tetrahydro-2H-pyran; 4-Fluorotetrahydropyran-4-ylmethanamine; (4-Fluorotetrahydro-2H-pyran-4-yl)methanamine; 4-Fluoro-4-(aminomethyl)oxane; 4-Fluorooxan-4-ylmethanamine; 4-Aminomethyl-4-fluorotetrahydropyran
EINECS	Contact for details

Quality Control

Our (4-Fluorotetrahydro-2H-Pyran-4-Yl)Methanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, GC, NMR, and MS to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.