Description

(4S)-6-Ethyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine is a chiral amine derivative of the benzopyran (chromane) class, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in the stereochemical purity of the (4S) enantiomer, which is essential for developing optically active compounds with specific biological activities. This high-purity intermediate is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the production of active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Building block for creating enantiomerically pure herbicides, fungicides, and plant growth regulators with enhanced efficacy and environmental profile.
• Asymmetric Catalysis Ligand Precursor: Used in the synthesis of chiral ligands for asymmetric hydrogenation and other catalytic transformations.
• Material Science Research: Intermediate for developing chiral organic frameworks, liquid crystals, or advanced polymers with specific optical properties.
• Academic & Contract Research: Serves as a standard or starting material in university and CRO laboratories for methodological studies in synthetic organic chemistry.

Basic Information

Product Name	(4S)-6-Ethyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine
CAS No.	1228566-51-5
Molecular Formula	C11H15NO
Molecular Weight	177.24 g/mol
Synonyms	(4S)-6-Ethylchroman-4-amine; (S)-6-Ethyl-3,4-dihydro-2H-chromen-4-amine; (S)-6-Ethyl-3,4-dihydro-2H-1-benzopyran-4-amine; (4S)-6-Ethyl-4-aminochroman; (S)-6-Ethylchroman-4-ylamine; 4-Amino-6-ethylchroman, (4S)-; 1228566-51-5; (S)-(-)-6-Ethyl-3,4-dihydro-2H-1-benzopyran-4-amine
EINECS	Contact for details

Quality Control

Our production of (4S)-6-Ethyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine adheres to stringent quality protocols suitable for pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. Our quality management system supports compliance with cGMP and ISO 9001 standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.