Description

(4R)-8-Ethyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine is a chiral amine derivative of a benzopyran scaffold, representing a high-value building block in advanced organic synthesis. This compound is critical for research and development in pharmaceutical chemistry, where its specific stereochemistry enables the creation of targeted bioactive molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutic agents and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthesis to introduce the (4R)-amine functionality into more complex molecular architectures.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probes: Used in the development of molecular probes to study enzyme function and biological pathways due to its amine handle for conjugation.
• Catalyst Ligand Precursor: Can be derivatized to form ligands for chiral catalysts used in enantioselective transformations.

Basic Information

Product Name	(4R)-8-Ethyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine
CAS No.	1228561-64-5
Molecular Formula	C11H15NO
Molecular Weight	177.24 g/mol
Synonyms	(4R)-8-Ethyl-3,4-dihydro-2H-chromen-4-amine; (R)-8-Ethyl-3,4-dihydro-2H-chromen-4-amine; (4R)-8-Ethylchroman-4-amine; 8-Ethyl-3,4-dihydro-2H-1-benzopyran-4-amine, (4R)-; (R)-8-Ethyl-3,4-dihydro-2H-1-benzopyran-4-amine; 4-Amino-8-ethylchroman, (4R)-; (4R)-4-Amino-8-ethyl-3,4-dihydro-2H-1-benzopyran
EINECS	Contact for details

Quality Control

Our (4R)-8-Ethyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine is manufactured under controlled conditions to ensure high chemical and chiral purity. Each batch undergoes rigorous analytical testing, including HPLC for chemical purity and chiral HPLC or polarimetry for enantiomeric excess (e.e.) verification. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.