Description

(4S)-8-Ethyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine is a chiral amine derivative of the benzopyran (chromane) class, serving as a critical chiral building block in advanced organic synthesis. Its value lies in its stereochemically defined structure, which is essential for imparting specific biological activity and physical properties in final target molecules. This high-purity intermediate is primarily needed by pharmaceutical R&D and fine chemical manufacturers developing novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Used in constructing chiral active ingredients for advanced pesticides and herbicides, where stereochemistry influences efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create other enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored optical or electronic properties.
• Academic & Industrial R&D: A valuable compound for methodological studies in organic chemistry and for exploring new synthetic routes to complex heterocycles.

Basic Information

Product Name	(4S)-8-Ethyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine
CAS No.	1228561-59-8
Molecular Formula	C11H15NO
Molecular Weight	177.24 g/mol
Synonyms	(4S)-8-Ethyl-3,4-dihydro-2H-chromen-4-amine; (4S)-8-Ethylchroman-4-amine; 8-Ethyl-3,4-dihydro-2H-1-benzopyran-4-amine, (4S)-; 4-Amino-8-ethylchroman, (S)-; (S)-8-Ethyl-3,4-dihydro-2H-chromen-4-amine; (S)-8-Ethyl-4-aminochroman; (4S)-8-Ethyl-4-amino-3,4-dihydro-2H-chromene
EINECS	Contact for details

Quality Control

Our (4S)-8-Ethyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), enantiomeric excess (ee), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.