Description

(S)-8-tert-Butylchroman-4-Amine CAS NO 1228553-77-2 is a high-purity chiral amine derivative of chroman, serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key chiral intermediate, enabling the development of enantiomerically pure pharmaceuticals and agrochemicals with targeted biological activity. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug discovery.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators where specific stereochemistry is crucial for efficacy.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Building Block: Employed in the multistep synthesis of complex natural products, flavors, and fragrances requiring the chroman scaffold.
• Academic & Industrial Research: A valuable reference standard and reagent for methodological studies in organic chemistry and medicinal chemistry programs.
• Material Science: Potential monomer or precursor for the synthesis of specialty polymers and advanced organic materials with specific optical properties.

Basic Information

Product Name	(S)-8-tert-Butylchroman-4-Amine
CAS No.	1228553-77-2
Molecular Formula	C₁₃H₁₉NO
Molecular Weight	205.30 g/mol
Synonyms	(S)-8-tert-Butyl-3,4-dihydro-2H-1-benzopyran-4-amine; (4S)-8-(1,1-Dimethylethyl)-3,4-dihydro-2H-1-benzopyran-4-amine; (S)-8-(tert-Butyl)chroman-4-amine; (S)-4-Amino-8-tert-butylchroman; 8-tert-Butylchroman-4-amine (S-enantiomer); (S)-8-tert-Butyl-4-aminochroman; (S)-8-tert-Butyl-3,4-dihydro-2H-chromen-4-amine
EINECS	Contact for details

Quality Control

Our (S)-8-tert-Butylchroman-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain product integrity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.