Description

(4R)-8-Chloro-3,4-Dihydro-2H-1-Benzopyran-4-Amine is a chiral benzopyran derivative of significant interest in advanced organic synthesis. This compound serves as a key chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process R&D, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical transformations.
• Fine Chemical Production: Serves as a building block for the synthesis of specialty chemicals and complex organic compounds.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(4R)-8-Chloro-3,4-Dihydro-2H-1-Benzopyran-4-Amine
CAS No.	1228542-42-4
Molecular Formula	C9H10ClNO
Molecular Weight	183.63 g/mol
Synonyms	(4R)-8-Chloro-3,4-dihydro-2H-chromen-4-amine; (4R)-8-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine; (R)-8-Chloro-3,4-dihydro-2H-chromen-4-amine; 8-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine, (4R)-; (4R)-8-Chloro-3,4-dihydro-2H-chromen-4-ylamine; (R)-8-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine; 1228542-42-4
EINECS	Contact for details

Quality Control

Our (4R)-8-Chloro-3,4-Dihydro-2H-1-Benzopyran-4-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for research and development applications. A detailed Certificate of Analysis (COA) with full spectroscopic data (NMR, MS, IR) and chromatographic profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.