Description

(4S)-8-Chloro-3,4-Dihydro-2H-Chromen-4-Amine is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. This compound is valued for its defined stereochemistry and functionalized chromane scaffold, which is crucial for the synthesis of targeted bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Serves as a versatile starting material or precursor for constructing complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Chemical Biology Probes: Employed in the development of molecular probes to study biological pathways and enzyme functions.
• Catalyst Ligand Precursor: Potential use in the synthesis of novel chiral ligands for asymmetric catalysis.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	(4S)-8-Chloro-3,4-Dihydro-2H-Chromen-4-Amine
CAS No.	1228542-35-5
Molecular Formula	C9H10ClNO
Molecular Weight	183.64 g/mol
Synonyms	(4S)-8-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine; (S)-8-Chloro-3,4-dihydro-2H-chromen-4-amine; 8-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine, (4S)-; 1228542-35-5; (S)-8-Chloro-3,4-dihydro-2H-chromane-4-amine; (4S)-8-Chloro-3,4-dihydro-2H-chromane-4-amine; (S)-8-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine
EINECS	Contact for details

Quality Control

Our (4S)-8-Chloro-3,4-Dihydro-2H-Chromen-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (HPLC), identity confirmation (IR, NMR), and impurity profiling to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.