Description

Pyrimidin-5-Ylzinc Bromide, 0.50 M In Thf is a highly reactive organozinc reagent, specifically formulated as a 0.50 molar solution in tetrahydrofuran (THF). This product is a critical building block for the efficient synthesis of complex heterocyclic compounds, enabling the rapid introduction of the pyrimidin-5-yl moiety under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for cross-coupling reactions, such as Negishi coupling, to construct novel molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing pyrimidine-based scaffolds in active pharmaceutical ingredients (APIs) and drug candidates.
• Negishi Cross-Coupling Reactions: Used as a nucleophilic coupling partner with aryl, heteroaryl, or vinyl halides to form new carbon-carbon bonds.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides containing pyrimidine rings.
• Material Science: Building block for creating organic electronic materials, ligands for catalysts, and specialty polymers.
• Chemical Biology & Medicinal Chemistry: Facilitates the synthesis of probe molecules and labeled compounds for biological testing.
• Process Chemistry & Scale-Up: Suitable for optimizing synthetic routes from laboratory to pilot plant scale due to its solution stability and defined concentration.

Basic Information

Product Name	Pyrimidin-5-Ylzinc Bromide, 0.50 M In Thf
CAS No.	1227941-02-7
Molecular Formula	C4H3N2ZnBr
Molecular Weight	224.38 g/mol
Synonyms	5-Pyrimidinylzinc bromide; Zinc, bromo(5-pyrimidinyl)-; Pyrimidin-5-ylzinc bromide solution; 5-Pyrimidylzinc bromide; (Pyrimidin-5-yl)zinc bromide; Bromo(pyrimidin-5-yl)zinc; Pyrimidin-5-yl zinc bromide THF solution; 0.5M Pyrimidin-5-ylzinc bromide in THF
EINECS	Contact for details

Quality Control

Every batch of Pyrimidin-5-Ylzinc Bromide solution is manufactured and analyzed under strict quality protocols to ensure consistency and reliability for sensitive synthetic applications. Our quality assurance includes rigorous testing for concentration, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing assay results, solvent content, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated area. Keep away from heat, sparks, and open flame. Due to its highly volatile and easily oxidized nature, the solution should be handled and transferred under an inert gas using standard syringe or cannula techniques.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Concentration (in THF)	0.50 M ± 0.05 M
Assay (Titration)	≥ 95% (relative to standard)
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.