Description

5-Iodo-1-Methyl-1H-Pyrazole-3-Carboxylic Acid is a high-purity, functionalized pyrazole derivative serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of a reactive iodine substituent and a carboxylic acid group, enabling versatile derivatization for creating complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators, leveraging its halogenated heterocyclic structure.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis due to its carboxylic acid functionality.
• Material Science: Employed in the synthesis of functional organic materials, such as metal-organic frameworks (MOFs) or organic semiconductors, where its specific geometry and reactivity are advantageous.
• Chemical Biology & Bioconjugation: The iodine atom can be utilized in cross-coupling reactions (e.g., Suzuki, Sonogashira) to attach fluorescent probes, affinity tags, or other biomolecules for diagnostic and research tools.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving diverse R&D projects.

Basic Information

Product Name	5-Iodo-1-Methyl-1H-Pyrazole-3-Carboxylic Acid
CAS No.	1227409-81-5
Molecular Formula	C5H5IN2O2
Molecular Weight	252.01 g/mol
Synonyms	1-Methyl-5-iodo-1H-pyrazole-3-carboxylic acid; 5-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid; 3-Carboxy-1-methyl-5-iodopyrazole; 1-Methyl-5-iodopyrazole-3-carboxylic acid; 5-Iodo-1-methylpyrazole-3-carboxylic acid; 1227409-81-5; 5-Iodo-1-methyl-1H-pyrazole-3-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Iodo-1-Methyl-1H-Pyrazole-3-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and NMR/IR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material that meets the stringent requirements for pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.