Description

1, 4, 7,10-Tetraazacyclododecane-1, 4, 7-Tris(Acetic Acid)-10-(2-Thioethyl)Acetamide is a sophisticated bifunctional chelating agent derived from the versatile cyclen (1,4,7,10-tetraazacyclododecane) macrocycle. This compound is engineered to provide a robust platform for creating stable metal complexes, primarily for diagnostic and therapeutic applications. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation radiopharmaceuticals and contrast agents. The product is supplied with a Certificate of Analysis to ensure batch-to-batch consistency and high purity for critical applications.

Application

• Radiopharmaceutical Precursor: Key intermediate for synthesizing technetium-99m (99mTc) and gallium-68 (68Ga) based diagnostic imaging agents for SPECT and PET scans.
• Therapeutic Agent Conjugation: Used to chelate therapeutic radionuclides like lutetium-177 (177Lu) or yttrium-90 (90Y) for targeted radionuclide therapy (TRT) in oncology.
• MRI Contrast Agent Development: Serves as a bifunctional chelator for gadolinium (Gd3+) in the research and development of novel magnetic resonance imaging (MRI) contrast media.
• Peptide and Antibody Labeling: Facilitates the site-specific conjugation of radioisotopes or other metal ions to targeting vectors such as peptides, antibodies, or antibody fragments.
• Molecular Imaging Probes: Enables the creation of multimodal imaging probes by combining different metal chelates for complementary diagnostic techniques.
• Research Chemical: Used in academic and industrial R&D for studying coordination chemistry, metal-ligand kinetics, and developing new chelation strategies.

Basic Information

Product Name	1, 4, 7,10-Tetraazacyclododecane-1, 4, 7-Tris(Acetic Acid)-10-(2-Thioethyl)Acetamide
CAS No.	1227407-76-2
Molecular Formula	C18H32N6O7S
Molecular Weight	476.55 g/mol
Synonyms	DO3A-SH; DO3A-Thioethylacetamide; 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic-10-(2-thioethyl)acetamide; 2-[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]-N-(2-sulfanylethyl)acetamide; DO3A monoamide thiol; Thiol-functionalized DO3A; Cyclen-based bifunctional chelator; 1,4,7-Tris(carboxymethyl)-10-[(2-mercaptoethyl)carbamoylmethyl]-1,4,7,10-tetraazacyclododecane
EINECS	Contact for details

Quality Control

Our production of 1, 4, 7,10-Tetraazacyclododecane-1, 4, 7-Tris(Acetic Acid)-10-(2-Thioethyl)Acetamide adheres to stringent quality protocols suitable for pharmaceutical research and development. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to confirm identity and purity. We provide comprehensive Certificates of Analysis (COA) detailing all critical quality attributes, ensuring traceability and compliance with your internal specifications. For custom synthesis or specific grade requirements, our technical team is available to discuss tailored QC parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.