Description

4-(Trifluoromethoxy)Cyclohexanecarboxylic Acid is a high-value fluorinated organic building block characterized by its cyclohexane backbone substituted with both a carboxylic acid and a trifluoromethoxy group. This unique structure makes it a critical intermediate for synthesizing advanced molecules with enhanced metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry for CNS, anti-inflammatory, and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group imparts improved activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Synthesis & Catalysis: A versatile reagent for introducing the trifluoromethoxy-cyclohexyl moiety into complex organic frameworks.
• Material Science Research: Employed in the development of specialty polymers and coatings with specific fluorinated properties.

Basic Information

Product Name	4-(Trifluoromethoxy)Cyclohexanecarboxylic Acid
CAS No.	1227187-82-7
Molecular Formula	C8H11F3O3
Molecular Weight	212.17 g/mol
Synonyms	4-(Trifluoromethoxy)cyclohexane-1-carboxylic acid; Cyclohexanecarboxylic acid, 4-(trifluoromethoxy)-; 4-(Trifluoromethoxy)-1-cyclohexanecarboxylic acid; 1-Carboxy-4-(trifluoromethoxy)cyclohexane; 4-TFMCA; 4-Trifluoromethoxycyclohexanecarboxylic acid; trans/cis-4-(Trifluoromethoxy)cyclohexanecarboxylic acid (mixture)
EINECS	Contact for details

Quality Control

Our production of 4-(Trifluoromethoxy)Cyclohexanecarboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed due to the compound's sensitivity to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.