Description

n-[(3-Bromophenyl)(2-Cyano-3-Fluorophenyl)Methylene]-2-Methyl-2-Propanesulfinamide CAS NO 1227162-82-4 is a high-purity, advanced pharmaceutical intermediate characterized by its sulfinamide functional group and halogenated aromatic structure. This compound is critical for facilitating asymmetric synthesis in the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of potential drug candidates, especially for central nervous system (CNS) and oncology targets.
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of chiral ligands for transition metal-catalyzed reactions, enabling enantioselective synthesis.
• Agrochemical Research: Serves as a sophisticated intermediate in the development of new-generation herbicides and pesticides with specific activity profiles.
• Material Science Chemistry: Employed in the research of organic electronic materials and liquid crystals due to its conjugated and halogenated system.
• Academic & Institutional R&D: A valuable reagent for methodological studies in organic synthesis, particularly in sulfinamide chemistry and cross-coupling reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.

Basic Information

Product Name	n-[(3-Bromophenyl)(2-Cyano-3-Fluorophenyl)Methylene]-2-Methyl-2-Propanesulfinamide
CAS No.	1227162-82-4
Molecular Formula	C₁₈H₁₆BrFN₂OS
Molecular Weight	407.30 g/mol
Synonyms	2-Methyl-2-propanesulfinamide, N-[(3-bromophenyl)(2-cyano-3-fluorophenyl)methylene]-; tert-Butanesulfinamide, N-[(3-bromophenyl)(2-cyano-3-fluorophenyl)methylene]-; (3-Bromophenyl)(2-cyano-3-fluorophenyl)methylideneamino tert-butyl sulfoxide; N-((3-Bromophenyl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide; B3C-F Sulfinamide; (E/Z)-N-[(3-Bromophenyl)(2-cyano-3-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide
EINECS	Contact for details

Quality Control

Our production of n-[(3-Bromophenyl)(2-Cyano-3-Fluorophenyl)Methylene]-2-Methyl-2-Propanesulfinamide adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization using HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting critical parameters. Our quality system is designed to support cGMP requirements for advanced intermediates, ensuring traceability and reliability for our global pharmaceutical and research clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Isomeric Ratio (E/Z)	Reported on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.