Description

2-[4-(4-Bromophenyl)-Tetrahydro-2H-Pyran-4-Yl]Acetic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique brominated phenyl-tetrahydropyran acetic acid structure. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel drug candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of complex molecular libraries for high-throughput screening.
• Academic & Institutional R&D: Employed in university and research institute laboratories for studying heterocyclic chemistry and developing new synthetic methodologies.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the scale-up and production of investigational new drugs (INDs) under cGMP conditions.

Basic Information

Product Name	2-[4-(4-Bromophenyl)-Tetrahydro-2H-Pyran-4-Yl]Acetic Acid
CAS No.	1226383-83-0
Molecular Formula	C13H15BrO3
Molecular Weight	299.16 g/mol
Synonyms	4-(4-Bromophenyl)-4-(carboxymethyl)tetrahydro-2H-pyran; 2-[4-(4-Bromophenyl)oxan-4-yl]acetic acid; 4-(4-Bromophenyl)tetrahydro-2H-pyran-4-acetic acid; 2-[4-(4-Bromophenyl)tetrahydro-2H-pyran-4-yl]ethanoic acid; (4-(4-Bromophenyl)tetrahydro-2H-pyran-4-yl)acetic acid; BRP-THP-AA; CAS 1226383-83-0
EINECS	Contact for details

Quality Control

Our 2-[4-(4-Bromophenyl)-Tetrahydro-2H-Pyran-4-Yl]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP requirements. Specifications are designed to meet the stringent needs of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.