Description

2-[4-(4-Fluorophenyl)-Tetrahydro-2H-Pyran-4-Yl]Acetic Acid is a high-value fluorinated organic building block with a unique pyran-acetic acid structure. This compound is critical for the synthesis of complex molecules, offering a versatile scaffold for introducing both fluorinated aromatic and carboxylic acid functional groups. It is primarily sought after by pharmaceutical and agrochemical research organizations for developing new active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional monomers for specialty polymers with tailored properties.
• Chemical Biology Probes: Utilized to create fluorinated probes for studying enzyme mechanisms and protein interactions.

Basic Information

Product Name	2-[4-(4-Fluorophenyl)-Tetrahydro-2H-Pyran-4-Yl]Acetic Acid
CAS No.	1226168-95-1
Molecular Formula	C13H15FO3
Molecular Weight	238.26 g/mol
Synonyms	4-(4-Fluorophenyl)tetrahydro-2H-pyran-4-acetic Acid; 2-[4-(4-Fluorophenyl)oxan-4-yl]acetic Acid; 4-(4-Fluorophenyl)-4-(carboxymethyl)tetrahydropyran; 2-(4-(4-Fluorophenyl)tetrahydro-2H-pyran-4-yl)acetic Acid; 4-(4-Fluorophenyl)-tetrahydro-2H-pyran-4-yl-acetic Acid; 1226168-95-1; 4-(4-Fluorophenyl)-4-(2-carboxyethyl)tetrahydropyran (tautomeric form)
EINECS	Contact for details

Quality Control

Our production of 2-[4-(4-Fluorophenyl)-Tetrahydro-2H-Pyran-4-Yl]Acetic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.