Description

2-(4-Bromophenyl)-1,1,1-Trifluoropropan-2-Yl Methanesulfonate is a high-value trifluoromethylated building block and methanesulfonate ester used in advanced organic synthesis. This compound is particularly significant for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where the introduction of fluorine atoms and specific functional groups is critical for modulating biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the bromophenyl and trifluoromethyl motifs are valuable.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) due to the presence of the bromine atom.
• Functional Group Transformation: The methanesulfonate (mesylate) group acts as an excellent leaving group for nucleophilic substitution reactions, enabling the introduction of various amines, alkoxides, and other nucleophiles.
• Material Science Research: Potential monomer or precursor for synthesizing specialty polymers and liquid crystals with unique electronic properties.
• Fluorine Chemistry: Essential for medicinal chemistry programs focused on fluorine scan or the development of CF3-containing bioactive molecules.

Basic Information

Product Name	2-(4-Bromophenyl)-1,1,1-Trifluoropropan-2-Yl Methanesulfonate
CAS No.	1225380-04-0
Molecular Formula	C11H10BrF3O3S
Molecular Weight	359.16 g/mol
Synonyms	1-(4-Bromophenyl)-2,2,2-trifluoroethyl methanesulfonate; 2,2,2-Trifluoro-1-(4-bromophenyl)ethyl methanesulfonate; α-(4-Bromophenyl)-α-(trifluoromethyl)methyl methanesulfonate; 4-Bromo-α-(trifluoromethyl)benzylmethanesulfonate; (4-Bromophenyl)(trifluoromethyl)methyl methanesulfonate; Mesylate ester of 2-(4-bromophenyl)-1,1,1-trifluoropropan-2-ol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards for advanced intermediates. Each batch is characterized by modern analytical techniques including HPLC, GC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We support our clients' regulatory needs with comprehensive documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.