Description

n-(9R)-Cinchonan-9-Yl-N'-[(2R)-2-Pyrrolidinylmethyl]-Thiourea is a sophisticated chiral thiourea derivative, a class of compounds renowned for their utility as organocatalysts and ligands in asymmetric synthesis. This high-purity compound is engineered to deliver exceptional enantioselectivity and yield in critical bond-forming reactions, directly addressing the need for reliable and efficient chiral induction in complex molecule construction. It is an essential research and development tool for pharmaceutical chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where stereochemical control is paramount.

Application

• Asymmetric Organocatalysis: Employed as a powerful hydrogen-bonding catalyst for enantioselective reactions such as Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: A critical reagent in the research and scale-up synthesis of chiral drug candidates and active pharmaceutical ingredients (APIs).
• Chiral Ligand for Metal Complexes: Can be utilized to create chiral metal-ligand complexes for asymmetric metal-catalyzed transformations.
• Methodology Development: Serves as a key compound in academic and industrial research for developing new catalytic asymmetric synthetic protocols.
• Agrochemical Research: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Applied in the manufacture of specialty chemicals where high stereochemical purity is required.

Basic Information

Product Name	n-(9R)-Cinchonan-9-Yl-N'-[(2R)-2-Pyrrolidinylmethyl]-Thiourea
CAS No.	1222966-44-0
Molecular Formula	C₂₅H₃₂N₄OS
Molecular Weight	436.61 g/mol
Synonyms	(9R)-N-[(2R)-2-Pyrrolidinylmethyl]-N'-(9-cinchonan-9-yl)thiourea; Cinchona Alkaloid-Derived Thiourea Catalyst; (R,R)-Thiourea Organocatalyst; Chiral Bifunctional Thiourea; Cinchonidine-Derived Thiourea; Asymmetric Synthesis Catalyst 1222966-44-0; N-[(9R)-Cinchonan-9-yl]-N'-[(2R)-2-pyrrolidinylmethyl]thiourea
EINECS	Contact for details

Quality Control

Our n-(9R)-Cinchonan-9-Yl-N'-[(2R)-2-Pyrrolidinylmethyl]-Thiourea is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and identity confirmation. We adhere to relevant industry standards for research-grade fine chemicals, ensuring the material is suitable for demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.