Description

n-(8α,9S)-Cinchonan-9-Yl-N'-[(2R)-2-Pyrrolidinylmethyl]-Thiourea is a high-purity, organocatalytic compound derived from cinchona alkaloid chemistry. This chiral thiourea derivative is valued for its role as a highly effective hydrogen-bond donor catalyst, enabling precise stereoselective transformations in complex synthetic pathways. It is an essential building block for researchers and manufacturers in the pharmaceutical and fine chemical industries developing novel active ingredients and advanced intermediates.

Application

• Asymmetric Organocatalysis: Serving as a privileged catalyst for enantioselective reactions such as Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: A key chiral scaffold in the research and development of new drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Fine Chemical Production: Enabling the synthesis of high-value, optically pure specialty chemicals and flavors & fragrances.
• Academic & Industrial R&D: A critical reagent for methodological development in synthetic organic chemistry and process chemistry optimization.
• Ligand for Metal Complexes: Potential use in designing chiral ligands for transition metal catalysis.

Basic Information

Product Name	n-(8α,9S)-Cinchonan-9-Yl-N'-[(2R)-2-Pyrrolidinylmethyl]-Thiourea
CAS No.	1222966-43-9
Molecular Formula	C₂₄H₃₂N₄OS
Molecular Weight	424.60 g/mol
Synonyms	(8α,9S)-N-[(2R)-2-Pyrrolidinylmethyl]-9-cinchonanamine thiourea; Cinchona Alkaloid Thiourea Derivative; (R)-Pyrrolidinylmethyl-Cinchona Thiourea; Organocatalyst 1222966-43-9; Hydrogen-Bond Donor (HBD) Catalyst; Chiral Bifunctional Thiourea; Cinchonidine-derived Thiourea; ASN 1222966-43-9
EINECS	Contact for details

Quality Control

Our production of this advanced chiral compound adheres to strict quality management systems. Every batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet the exacting standards required for catalysis and synthesis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from HPLC, NMR, and optical rotation analyses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.