Description

n-(9R)-Cinchonan-9-Yl-N'-[(2S)-2-Pyrrolidinylmethyl]-Thiourea is a sophisticated chiral thiourea derivative, structurally derived from cinchona alkaloids, designed for high-performance asymmetric catalysis. This compound matters for its exceptional ability to act as a bifunctional organocatalyst, facilitating enantioselective transformations critical for producing single-isomer pharmaceuticals and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors who require precise stereochemical control in synthetic pathways.

Application

• Asymmetric Organocatalysis: Employed as a powerful bifunctional catalyst for enantioselective Michael additions, Mannich reactions, and aldol condensations.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of chiral active pharmaceutical ingredients (APIs) where high enantiomeric purity is mandatory.
• Fine Chemical Production: Facilitates the synthesis of complex, optically pure molecules for fragrances, flavors, and advanced materials.
• Academic & Industrial Research: Serves as a key reagent in methodological studies and process development for new catalytic asymmetric reactions.
• Ligand for Metal Complexes: Can be utilized in the design of chiral ligands for transition metal catalysis, expanding its utility in hybrid catalytic systems.

Basic Information

Product Name	n-(9R)-Cinchonan-9-Yl-N'-[(2S)-2-Pyrrolidinylmethyl]-Thiourea
CAS No.	1222966-36-0
Molecular Formula	C₂₅H₃₂N₄OS
Molecular Weight	436.61 g/mol
Synonyms	(9R)-N-[(2S)-2-Pyrrolidinylmethyl]-N'-(9-cinchonan-9-yl)thiourea; Cinchona Alkaloid-Derived Thiourea Organocatalyst; Bifunctional Cinchona Thiourea Catalyst; (R)-Cinchonidine-Based Thiourea; (9R)-Cinchonan-9-yl-N-[(2S)-2-pyrrolidinylmethyl]thiourea; Asymmetric Thiourea Organocatalyst; Chiral Thiourea Derivative; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our n-(9R)-Cinchonan-9-Yl-N'-[(2S)-2-Pyrrolidinylmethyl]-Thiourea is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and key analytical data from techniques including HPLC, NMR, and mass spectrometry. We are committed to meeting the stringent requirements of our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.