Description

(3Ar,5R)-3A,4,5,7-Tetrahydro-5-Methyl-3H-Pyrano[3,4-C]Isoxazole is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and fused heterocyclic structure. This compound is of significant value for its role as a critical building block in the synthesis of novel, complex active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new bioactive molecules.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for new API manufacturing.
• Asymmetric Synthesis: Utilized as a stereodefined scaffold for constructing complex molecular architectures with high enantiomeric purity.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring specialized heterocyclic chemistry.
• Academic Research: Used in university laboratories for studying novel organic reactions and heterocyclic compound properties.

Basic Information

Product Name	(3Ar,5R)-3A,4,5,7-Tetrahydro-5-Methyl-3H-Pyrano[3,4-C]Isoxazole
CAS No.	1220327-45-6
Molecular Formula	C8H11NO2
Molecular Weight	153.18 g/mol
Synonyms	(3aR,5R)-3a,4,5,7-Tetrahydro-5-methyl-3H-pyrano[3,4-c]isoxazole; (3aR,5R)-5-Methyl-3a,4,5,7-tetrahydro-3H-pyrano[3,4-c]isoxazole; 5-Methyl-3a,4,5,7-tetrahydro-3H-pyrano[3,4-c]isoxazole (enantiomer); Pyrano[3,4-c]isoxazole derivative; Fused isoxazole-pyrone intermediate; Chiral pyranoisoxazole
EINECS	Contact for details

Quality Control

Our (3Ar,5R)-3A,4,5,7-Tetrahydro-5-Methyl-3H-Pyrano[3,4-C]Isoxazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and development grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee reproducible results for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.