Description

2-Fluoro-n-1-Methyl-n-1-(Tetrahydro-2H-Pyran-4-Ylmethyl)-1,4-Benzenediamine is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need this specialized intermediate to develop next-generation drug candidates, leveraging its unique fluorine-substituted benzenediamine core.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its fluorine atom and tetrahydro-2H-pyran moiety.
• API Development: Serves as a precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Utilized in the development of specialized probes for studying enzyme inhibition and receptor binding.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development.
• Academic Research: Used in university and institutional labs for exploratory organic synthesis and new reaction methodology development.

Basic Information

Product Name	2-Fluoro-n-1-Methyl-n-1-(Tetrahydro-2H-Pyran-4-Ylmethyl)-1,4-Benzenediamine
CAS No.	1220037-51-3
Molecular Formula	C14H19FN2O
Molecular Weight	250.31 g/mol
Synonyms	1,4-Benzenediamine, 2-fluoro-N1-methyl-N1-[(tetrahydro-2H-pyran-4-yl)methyl]-; 2-Fluoro-N1-methyl-N1-(tetrahydro-2H-pyran-4-ylmethyl)benzene-1,4-diamine; 4-Amino-2-fluoro-N-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)aniline; 2-Fluoro-N-methyl-N-(oxan-4-ylmethyl)benzene-1,4-diamine; CAS 1220037-51-3; Fluorinated Benzenediamine Derivative; THP-Protected Fluoroaniline Intermediate
EINECS	Contact for details

Quality Control

Our 2-Fluoro-n-1-Methyl-n-1-(Tetrahydro-2H-Pyran-4-Ylmethyl)-1,4-Benzenediamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.