Description

n-(5-Amino-2-Chlorophenyl)Tetrahydro-2H-Pyran-4-Carboxamide is a high-purity, advanced pharmaceutical intermediate with a distinct molecular architecture. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), where its specific functional groups enable targeted chemical transformations. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new therapeutic agents and crop protection products. The compound is identified by CAS No. 1220020-61-0.

Application

This specialized intermediate serves as a key building block in several high-value synthetic pathways. Its primary applications include:

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel small-molecule drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging its chlorophenyl and carboxamide functionalities.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	n-(5-Amino-2-Chlorophenyl)Tetrahydro-2H-Pyran-4-Carboxamide
CAS No.	1220020-61-0
Molecular Formula	C12H15ClN2O2
Molecular Weight	254.71 g/mol
Synonyms	4-Pyrancarboxamide, N-(5-amino-2-chlorophenyl)tetrahydro-; Tetrahydro-2H-pyran-4-carboxamide, N-(5-amino-2-chlorophenyl)-; 1220020-61-0; N-(5-Amino-2-chlorophenyl)oxane-4-carboxamide; N-(5-Amino-2-chlorophenyl)tetrahydropyran-4-carboxamide; 5-Amino-2-chloro-N-(tetrahydro-2H-pyran-4-yl)benzamide
EINECS	Contact for details

Quality Control

Our n-(5-Amino-2-Chlorophenyl)Tetrahydro-2H-Pyran-4-Carboxamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.